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    1. Neuroscience

    Drosophila TRPγ is required in neuroendocrine cells for post-ingestive food selection

    Subash Dhakal, Qiuting Ren ... Youngseok Lee
    Genetic, behavioral, and biochemical evidence reveals that the Drosophila TRPγ channel is required in neuroendocrine cells for the starvation-induced switch in preference to less palatable but more nutritive food.
    1. Immunology and Inflammation

    Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

    Claudio Tripodo, Barbara Bassani ... Sabina Sangaletti
    Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.
    1. Cell Biology
    2. Neuroscience

    Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

    Soo Jeong Kim, Youngsik Woo ... Sang Ki Park
    Rai14-Tara complex enhances the stability of dendritic spines and synaptic connections relevant to depressive-like behaviors.
    1. Evolutionary Biology

    Computed tomographic analysis of the dental system of three Jurassic ceratopsians and implications for the evolution of tooth replacement pattern and diet in early-diverging ceratopsians

    Jinfeng Hu, Catherine A Forster ... Fenglu Han
    The tooth replacement pattern of early-diverging ceratopsians helps to understand the origin of the specialized dental system of ceratopsids and provides new insights to feeding strategy transition.
    1. Cancer Biology
    2. Genetics and Genomics

    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

    Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz ... Pau Castel
    Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
    1. Genetics and Genomics

    Boosting targeted genome editing using the hei-tag

    Thomas Thumberger, Tinatini Tavhelidse-Suck ... Joachim Wittbrodt
    Increased efficiency of targeted genome editing by simple addition of a bipartite-optimized tag at the N- and C-termini of effector proteins (Cas9 and cytosine-to-thymine base editor) is applicable in organismo and cell culture.
    1. Neuroscience

    Competition between parallel sensorimotor learning systems

    Scott T Albert, Jihoon Jang ... Reza Shadmehr
    When a common error drives parallel implicit and explicit learning systems, increases in the explicit response will suppress implicit adaptation.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    De novo-designed transmembrane domains tune engineered receptor functions

    Assaf Elazar, Nicholas J Chandler ... Sarel J Fleishman
    Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
    1. Computational and Systems Biology
    2. Neuroscience

    Early lock-in of structured and specialised information flows during neural development

    David P Shorten, Viola Priesemann ... Joseph T Lizier
    In developing neural cell cultures, information flows lock-in early and nodes undertake specialised computational roles.
    1. Cell Biology

    Condensation of Ede1 promotes the initiation of endocytosis

    Mateusz Kozak, Marko Kaksonen
    Protein phase separation provides an explanation for the compositional flexibility of endocytic initiation and the role of multivalent disordered scaffolds in endocytosis.