Genetic, behavioral, and biochemical evidence reveals that the Drosophila TRPγ channel is required in neuroendocrine cells for the starvation-induced switch in preference to less palatable but more nutritive food.
Claudio Tripodo, Barbara Bassani ... Sabina Sangaletti
Neutrophil extracellular traps are an immunogenic source of leukemia antigens in dendritic cell-based vaccination and are able to instruct antileukemia CD8 T-cell responses.
The tooth replacement pattern of early-diverging ceratopsians helps to understand the origin of the specialized dental system of ceratopsids and provides new insights to feeding strategy transition.
Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz ... Pau Castel
Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
Thomas Thumberger, Tinatini Tavhelidse-Suck ... Joachim Wittbrodt
Increased efficiency of targeted genome editing by simple addition of a bipartite-optimized tag at the N- and C-termini of effector proteins (Cas9 and cytosine-to-thymine base editor) is applicable in organismo and cell culture.
Assaf Elazar, Nicholas J Chandler ... Sarel J Fleishman
Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.
Protein phase separation provides an explanation for the compositional flexibility of endocytic initiation and the role of multivalent disordered scaffolds in endocytosis.