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Page 669 of 1,751
    1. Structural Biology and Molecular Biophysics

    Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

    Nicolai Tidemand Johansen, Marta Bonaccorsi ... Lise Arleth
    The Mg2+-channel CorA explores a wide conformational landscape of non-conducting states irrespective of bound Mg2+, but only in abscence of Mg2+, conducting states become accessible due to increased backbone dynamics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells

    Dorottya Anna Simon, András Tálas ... Ervin Welker
    Prime editor activity reporter (PEAR) is a flexible fluorescent reporter that identifies and enriches prime edited cells.
    1. Cell Biology
    2. Genetics and Genomics

    Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

    Tobias Gerber, Cristina Loureiro ... J Gray Camp
    Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
    1. Neuroscience

    Unsupervised learning of haptic material properties

    Anna Metzger, Matteo Toscani
    Perceptual haptic representation of materials emerges from unsupervised learning as a consequence of efficient encoding of the physical signals at the input of tactile sensory system.
    1. Immunology and Inflammation

    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

    Yang Yang, Jing Wu ... Lin Wei
    New insight into non-bactericidal cathelicidin against bacterial infection.
    1. Developmental Biology
    2. Physics of Living Systems

    Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye

    Kevin D Gallagher, Madhav Mani, Richard W Carthew
    Formation of a triangular lattice of photoreceptor clusters in the compound eye is driven by highly regulated cell flows in the eye epithelium, through a mechanochemical mechanism.
    1. Microbiology and Infectious Disease

    Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

    R Christopher D Furniss, Nikol Kaderabkova ... Despoina AI Mavridou
    Disruption of disulfide bond formation sensitizes resistant Gram-negative bacteria expressing β-lactamases and mobile colistin resistance enzymes to currently available antibiotics.
    1. Plant Biology

    Plant SYP12 syntaxins mediate an evolutionarily conserved general immunity to filamentous pathogens

    Hector M Rubiato, Mengqi Liu ... Mads E Nielsen
    To effectively ward off some of the most damaging groups of filamentous pathogens, plants rely on an evolutionarily conserved syntaxin function to block the pathogen from entering the host cell and proliferate.
    1. Cell Biology
    2. Developmental Biology

    Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis

    Eric Paulissen, Nicholas J Palmisano ... Benjamin L Martin
    Retinoic acid-dependent somite morphogenesis induces notochord-endoderm separation required for midline angioblast migration and axial blood vessel development.
    1. Cell Biology
    2. Immunology and Inflammation

    Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

    Miaomiao Li, Chih Yean Ong ... Ding Xu
    Heparan sulfate-RAGE interaction is essential for normal function of RAGE in osteoclastogenesis and drug-induced liver damage, which can be targeted to curb RAGE activation as a new opportunity.