Pioneering activity may be a property of all transcription factors with sufficient affinity for their targets rather than a property of specific classes of transcription factors.
Genetic analysis and biochemical approaches reveal that chemorefractory properties are reversed by inhibiting mucin secretion, thus providing a means to curb the growth and spread of colorectal cancer.
Yannick Becker, Nicolas Claidière ... Adrien Meguerditchian
A brain MRI imaging study on brain and manual lateralisation in 50 baboons shows that communicative manual gesturing is related to a Broca's area marker.
Development of imaging methods to capture neural activity and structure through the intact cuticle using 2-photon and 3-photon excitation in the genetic model organism, Drosophila melanogaster.
Ethan Ozment, Arianna N Tamvacakis ... Nagayasu Nakanishi
Developmental genetics of sea anemone mechanosensory neurons provides insights into the deep evolutionary history of mechanoreceptor development in animals.
An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.
The Spike gene expressed by the vector-based vaccine Vaxzevria bears the risk of cryptic splicing, which in turn may lead to cellular production of soluble, instead of membrane-anchored, Spike protein variants.
Double-stranded precursors of siRNAs involved in RNA-directed DNA methylation have initiating sequences and overhangs imparted by the RNA polymerases that synthesize them, programming alternative dicing reactions that diversify the siRNA pool.
Rachael E Barton, Lucia F Massari ... Adèle L Marston
Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.
Ling-Qi Zhang, Nicolas P Cottaris, David H Brainard
A computational model of the initial visual encoding together with Bayesian image reconstruction quantifies how that encoding, combined with the statistical regularities of natural images, shapes key aspects of visual perception.