Browse our latest research

Page 674 of 1,751
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A test of the pioneer factor hypothesis using ectopic liver gene activation

    Jeffrey L Hansen, Kaiser J Loell, Barak A Cohen
    Pioneering activity may be a property of all transcription factors with sufficient affinity for their targets rather than a property of specific classes of transcription factors.
    1. Cell Biology

    Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

    Gerard Cantero-Recasens, Josune Alonso-Marañón ... Vivek Malhotra
    Genetic analysis and biochemical approaches reveal that chemorefractory properties are reversed by inhibiting mucin secretion, thus providing a means to curb the growth and spread of colorectal cancer.
    1. Neuroscience

    Broca's cerebral asymmetry reflects gestural communication's lateralisation in monkeys (Papio anubis)

    Yannick Becker, Nicolas Claidière ... Adrien Meguerditchian
    A brain MRI imaging study on brain and manual lateralisation in 50 baboons shows that communicative manual gesturing is related to a Broca's area marker.
    1. Neuroscience

    Multiphoton imaging of neural structure and activity in Drosophila through the intact cuticle

    Max Jameson Aragon, Aaron T Mok ... Nilay Yapici
    Development of imaging methods to capture neural activity and structure through the intact cuticle using 2-photon and 3-photon excitation in the genetic model organism, Drosophila melanogaster.
    1. Developmental Biology
    2. Evolutionary Biology

    Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity

    Ethan Ozment, Arianna N Tamvacakis ... Nagayasu Nakanishi
    Developmental genetics of sea anemone mechanosensory neurons provides insights into the deep evolutionary history of mechanoreceptor development in animals.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

    Wai Hoe Ng, Elizabeth K Johnston ... Xi Ren
    An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Vaccine-induced COVID-19 mimicry syndrome

    Eric Kowarz, Lea Krutzke ... Rolf Marschalek
    The Spike gene expressed by the vector-based vaccine Vaxzevria bears the risk of cryptic splicing, which in turn may lead to cellular production of soluble, instead of membrane-anchored, Spike protein variants.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A DCL3 dicing code within Pol IV-RDR2 transcripts diversifies the siRNA pool guiding RNA-directed DNA methylation

    Andrew Loffer, Jasleen Singh ... Craig S Pikaard
    Double-stranded precursors of siRNAs involved in RNA-directed DNA methylation have initiating sequences and overhangs imparted by the RNA polymerases that synthesize them, programming alternative dicing reactions that diversify the siRNA pool.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

    Rachael E Barton, Lucia F Massari ... Adèle L Marston
    Meiotic recombination and chromosome segregation require the establishment of chromatin boundaries by the acetyltransferase Eco1, which anchors both chromatin loops and cohesion.
    1. Computational and Systems Biology
    2. Neuroscience

    An image reconstruction framework for characterizing initial visual encoding

    Ling-Qi Zhang, Nicolas P Cottaris, David H Brainard
    A computational model of the initial visual encoding together with Bayesian image reconstruction quantifies how that encoding, combined with the statistical regularities of natural images, shapes key aspects of visual perception.