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    1. Evolutionary Biology

    Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin’s Paradox

    Vince Buffalo
    Quantifying the relationship between census sizes and genetic diversity estimates provides insights into whether natural selection can explain the narrow range of diversity between species.
    1. Neuroscience

    Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

    Ella Podvalny, Leana E King, Biyu J He
    Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.
    1. Microbiology and Infectious Disease

    Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

    Michael J Sheedlo, Clarissa L Durie ... Melanie D Ohi
    Structural analysis of the type IV secretion system purified from Legionella pneumophila uncovers new complex components and symmetry mismatches.
    1. Neuroscience

    Diverse inhibitory projections from the cerebellar interposed nucleus

    Elena N Judd, Samantha M Lewis, Abigail L Person
    Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
    1. Cell Biology
    2. Developmental Biology

    PRMT5 regulates ovarian follicle development by facilitating Wt1 translation

    Min Chen, Fangfang Dong ... Fei Gao
    PRMT5 participates in ovarian granulosa cell lineage maintenance by regulating Wt1 IRES-dependent translation.
    1. Cell Biology
    2. Plant Biology

    Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

    Yuan Zhou, Prativa Amom ... Anna A Dobritsa
    Pollen aperture patterning in Arabidopsis is controlled by members of the ELMOD protein family, whose expression levels in developing pollen lineage are tightly regulated.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

    Vishwa Patel, Nishad Matange
    Mutations in gene regulatory proteins set the stage for the evolution of antimicrobial resistance by shifting the fitness landscape of resistance-conferring mutations.
    1. Cancer Biology
    2. Medicine

    Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking

    Shuhua Cheng, Wei Zhang ... Wayne Tam
    Comparative analysis establishes genetic links among angioimmunoblastic T-cell lymphoma (AITL), clonal hematopoiesis, and concomitant hematologic malignancies, and provides insights into the cell of origin, etiology, and biomarker discovery for AITL.
    1. Neuroscience

    Temporo-cerebellar connectivity underlies timing constraints in audition

    Anika Stockert, Michael Schwartze ... Sonja A Kotz
    With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

    Michael I Barton, Stuart A MacGowan ... P Anton van der Merwe
    Common variants of the SARS-CoV-2 Spike protein and its ligand, the human ACE2 receptor, increase the binding affinity, suggesting that they could increase viral transmissibility.