Sharon R Ladyman, Kirsten M Carter ... David R Grattan
Despite voluntary exercise being rewarding to mice, pregnancy hormones act in the maternal brain to markedly reduce the time females choose to engage in this activity.
Brandon G Rasman, Patrick A Forbes ... Jean-Sébastien Blouin
The nervous system can learn to control standing balance with added sensorimotor delays by causally linking delayed whole-body sensory feedback, initially deemed as unexpected, to self-generated balance motor commands.
Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
Angela R Garcia, Caleb Finch ... Benjamin C Trumble
The relationship between APOE genotype and disease risks may be environmentally moderated, with APOE4 being less harmful and unlikely to increase cardiometabolic risk in a physically active, energy-limited population.
Konstantinos Gkatzis, Paolo Panza ... Didier YR Stainier
A serum-free organotypic culture model of mouse lung epithelial progenitors was developed and used to screen WNT modulators for regulators of epithelial differentiation.
Mohammad Mofatteh, Fabio Echegaray-Iturra ... Mustafa G Aydogan
Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but have evolved to run independently to regulate different cellular events.
The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
Exposing subjects to the magnetic field of an MRI scanner stimulates the vestibular organ and thereby induces a horizontal bias of spatial orienting and exploration similar to that seen in stroke patients with spatial neglect.
Jessica P Kuppan, Margaret D Mitrovich, Michael D Vahey
Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.
Radial alignment in confined cell monolayers with isotropic actin network is found to be mediated by the condensation tendency and tissue-scale actin gradient.
