Browse our latest research

Page 819 of 1,838
    1. Cell Biology
    2. Developmental Biology

    SLC1A5 provides glutamine and asparagine necessary for bone development in mice

    Deepika Sharma, Yilin Yu ... Courtney M Karner
    Osteoblasts utilize an elegant mechanism by which they obtain and subsequently synthesize the requisite amino acids to support osteoblast differentiation and bone formation.
    1. Cell Biology

    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

    Saeed Daneshmandi, Teresa Cassel ... Pankaj Seth
    6-Phosphogluconate dehydrogenase controls regulatory T cells metabolism with shifts to Th1, Th2, and Th17 phenotypes.
    1. Computational and Systems Biology
    2. Neuroscience

    Evolving interpretable plasticity for spiking networks

    Jakob Jordan, Maximilian Schmidt ... Mihai A Petrovici
    Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.
    1. Chromosomes and Gene Expression
    2. Medicine

    Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

    Tamara Garrido-Gomez, Nerea Castillo-Marco ... Carlos Simon
    The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.
    1. Neuroscience

    The OpenNeuro resource for sharing of neuroscience data

    Christopher J Markiewicz, Krzysztof J Gorgolewski ... Russell Poldrack
    OpenNeuro is a data sharing archive that provides a platform for the free and open sharing of a broad range of neuroscience data types.
    1. Cell Biology

    Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation

    Hiroko Katsuno-Kambe, Jessica L Teo ... Alpha S Yap
    Integrin- and ERK signaling stimulates mammary epithelial cell proliferation when extracellular collagen condenses, causing asymmetric growth of multicellular aggregates that is necessary for elongation during branching morphogenesis.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Early prediction of in-hospital death of COVID-19 patients: a machine-learning model based on age, blood analyses, and chest x-ray score

    Emirena Garrafa, Marika Vezzoli ... Roberto Maroldi
    An early-warning model able to predict in-hospital mortality in patients affected by COVID-19 was developed and validated using common and economic tools.
    1. Cell Biology
    2. Neuroscience

    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

    Shahzad S Khan, Yuriko Sobu ... Suzanne R Pfeffer
    Striatal cholinergic interneurons and astrocytes lose cilia and show dysregulation of Hedgehog signaling in mice with a Parkinson's disease-associated, G2019S LRRK2 mutation or upon loss of PPM1H phosphatase specific for LRRK2-phosphorylated Rab GTPases.
    1. Neuroscience

    Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

    Taisuke Miyazaki, Megumi Morimoto-Tomita ... Susumu Tomita
    Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.
    1. Neuroscience

    Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex

    Timothy T Rogers, Christopher R Cox ... Matthew A Lambon Ralph
    Signals recorded directly from human anterior temporal cortex reveal that the brain represents animacy information using a distributed code that changes radically as a stimulus is processed, as predicted by an artificial neural network model.