Jordana K Thibado, Jean-Yves Tano ... Joshua Levitz
Homo- and heterodimeric group II metabotropic glutamate receptors show diverse modes of interaction between transmembrane domains that control their distinct assembly and activation properties.
Asha Mary Joseph, Saheli Daw ... Anjana Badrinarayanan
Live-cell imaging shows that replication-independent specialized polymerase action is a consequence of lesion processing via NER and impacts cellular survival under stress outside replicative phases of the cell cycle.
Rediet Zewdu, Elnaz Mirzaei Mehrabad ... Eric L Snyder
Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
Alexander Fengler, Lakshmi N Govindarajan ... Michael J Frank
A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
Stephan Wilmes, Polly-Anne Jeffrey ... Ignacio Moraga
IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
