Shikai Hu, Jacquelyn O Russell ... Satdarshan P Monga
Ductular reaction often observed in chronic liver pathologies such as in cystic fibrosis could be due to disruption of a novel complex of β-catenin-NF-κB and CFTR in cholangiocytes, which leads to persistent nuclear translocation of p65 and NF-κB activation.
A unique toolbox of novel mouse lines expressing optical effectors and sensors in cardiovascular, smooth muscle, and additional lineages allows extensive in vivo and ex vivo analysis of complex biological systems.
Mechanically activated Piezo1 ion channels, at physiologically relevant densities, behave as independent mechanotransducers, which we propose is essential for homogenous transduction of forces across the entire cell membrane.
People use vmPFC-dependent forward thinking to guide social choices and exploit the controllability of social environments, expanding the role of this neurocomputational mechanism beyond spatial and cognitive mapping.
Helen R McPherson, Cedric Duval ... Robert AS Ariëns
Fibrinogen, a key protein involved in blood coagulation, contains a disordered and previously poorly characterised region called αC that plays a critical role in fibrin fibre growth and clot stability.
A fluorescence-based pre-screening strategy allows high-throughput, convenient, and fast gross assessment of resected tumor margins by imaging cytoplasmic viscosity and hypoxia.
To facilitate human developmental biology research, CRISPR-mediated homologous recombination, tightly inducible gene knockdowns (CRISPRi) and overexpression (CRISPRa) have been efficiently applied to human organoids.
E Josue Ruiz, Adan Pinto-Fernandez ... Axel Behrens
Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.
Fast network oscillations in the mammalian main olfactory bulb emerge from the dense synchronization of gamma-frequency firing among resonant tufted cells.
Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.
