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Page 843 of 1,838
    1. Neuroscience

    The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

    Casey Paquola, Jessica Royer ... Boris Bernhardt
    The BigBrainWarp toolbox facilitates integration of 3D human brain histology with neuroimaging, helping neuroscientists to utilise cytoarchitectural information in conjunction with in vivo imaging.
    1. Neuroscience

    Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

    Gabriella R Sterne, Hideo Otsuna ... Kristin Scott
    A split-GAL4 collection provides precise genetic targeting of 138 neuronal cell types in the subesophageal zone of adult Drosophila melanogaster.
    1. Stem Cells and Regenerative Medicine

    Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

    Diptiman Chanda, Mohammad Rehan ... Victor J Thannickal
    Lung stem cell niche aging is associated with altered bioenergetics, metabolic dysfunction, and senescence of mesenchymal stromal cells that restricts 3D organoid, or alveolosphere formation, potentially accounting for reduced regenerative capacity with aging.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen

    Ursula Oggenfuss, Thomas Badet ... Daniel Croll
    The activation of transposable elements and relaxed purifying selection underpin an incipient expansion of the genome in populations of a major wheat pathogen.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz, Maksim A Yakovlev ... Keith C Cheng
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Neuroscience

    Neural dynamics between anterior insular cortex and right supramarginal gyrus dissociate genuine affect sharing from perceptual saliency of pretended pain

    Yili Zhao, Lei Zhang ... Claus Lamm
    Seeing others genuinely experiencing pain vs. pretending to be in pain is distinctively tracked by neural processes related to affect sharing and self-other distinction, enabling individuals to precisely respond to others’ actual emotions and needs.
    1. Neuroscience

    L-DOPA modulates activity in the vmPFC, nucleus accumbens, and VTA during threat extinction learning in humans

    Roland Esser, Christoph W Korn ... Jan Haaker
    Encoding an expected, but absent, threat is modulated by dopaminergic neurotransmission that regulates success of extinction learning in humans.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

    Teresa Romeo Luperchio, Leandros Boukas ... Hans T Bjornsson
    Chromatin/transcriptome profiling in multiple mouse models with mutations in epigenetic machinery (EM) reveals shared abnormalities including many IgA-relevant genes, indicating that this kind of joint analysis may elucidate the multigenic nature of EM disorders.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla, Marcos Assis Nascimento ... Arturo Álvarez-Buylla
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Drosophila STING protein has a role in lipid metabolism

    Katarina Akhmetova, Maxim Balasov, Igor Chesnokov
    Drosophila STING protein, or stimulator of interferon genes, has a direct but previously unknown role in the lipid metabolism.