Browse our latest research

Page 849 of 1,838
    1. Cell Biology
    2. Developmental Biology

    Quantitative mapping of dense microtubule arrays in mammalian neurons

    Eugene A Katrukha, Daphne Jurriens ... Lukas C Kapitein
    Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.
    1. Cancer Biology

    A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

    Joanna L Gillis, Josephine A Hinneh ... Lisa M Butler
    A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation, survival and intracellular redox control.
    1. Cell Biology
    2. Developmental Biology

    Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

    Mor Levi-Ferber, Rewayd Shalash ... Sivan Henis-Korenblit
    Neuronal circuits can be disrupted by ire-1-dependent mRNA decay to affect germline tumor cell identity by regulating cross-tissue communication in Caenorhabditis elegans.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells

    Bo-Ruei Chen, Yinan Wang ... Barry P Sleckman
    The LIN37-DREAM complex has a critical role in regulating DNA double-strand break end processing and suppressing aberrant homology-directed repair in quiescent cells.
    1. Biochemistry and Chemical Biology

    Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

    Maxime Louet, Marina Casiraghi ... Jean-Louis Banères
    A combination of state-of-the-art biochemical, biophysical, and computational methods revealed that water molecules play a central role in signal propagation through G protein-coupled receptors.
    1. Cell Biology
    2. Developmental Biology

    Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish

    Meredith H Wilson, Stephen C Ekker, Steven A Farber
    Fluorescent perilipin zebrafish lines are powerful new tools for studying lipid droplet dynamics in health and disease.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The roles of history, chance, and natural selection in the evolution of antibiotic resistance

    Alfonso Santos-Lopez, Christopher W Marshall ... Vaughn S Cooper
    Selection imposed by antibiotics may dominate evolutionary forces acting on opportunistic pathogens like Acinetobacter baumannii, yet chance effects and a prior history in biofilm may constrain resistance and impose collateral sensitivities.
    1. Cell Biology

    A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

    Xiao Zhang, Hero Robles ... Erica L Scheller
    A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age and in states of metabolic stress.
    1. Cell Biology
    2. Immunology and Inflammation

    Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

    Andrea Santeford, Aaron Y Lee ... Rajendra S Apte
    MicroRNA-146b regulates aging, activation, and mitochodrial function in thioglycollate-elicited peritoneal macrophages.
    1. Neuroscience

    Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs

    Ara Schorscher-Petcu, Flóra Takács, Liam E Browne
    A system to generate ‘remote touch’ in freely behaving mice can be utilized to map behavior caused by precise somatosensory inputs.