Browse our latest research

Chromatin remodeling enzymes perform target search by utilizing ATP-binding and hydrolysis to facilitate 1D-diffusion on and rapid detachment from chromatin in living yeast.

Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.

MicroRNA-mediated repression of a DNA methyltransferase prevents the ectopic methylation of thousands of genes based on distinct chromatin features during embryogenesis, which can reduce expression and persist for weeks afterwards.

Doublecortin-like kinase 1 modulates its own kinase activity to tune its microtubule-binding affinity, providing molecular insights into a unique form of autoregulatory control over microtubule-binding activity.

The dorsal part of the primate caudate head signals integrated multi-dimensional incentive factors essential for computing the motivation for action.

Different subtypes of projection neurons in the mouse olfactory bulb are defined by distinct gene expression patterns and transcription factor networks.

Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.

Filopodia formation requires recruitment and activation of myosin through generation of parallel, bundled actin filaments by VASP polymerase, revealing coupling between motor activation and organization of a local actin network.

Measurement of physiological intracellular Ca²⁺ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.

The genetic background of Saccharomyces cerevisiae yeast strains influences responses to gene overexpression.