Heterotypic immunity, the ability of immunity induced by one SARS-CoV-2 variant to protect against another, is asymmetric, with the UK (B.1.1.7) variant, eliciting weaker heterotypic immunity than other variants.
Martin H Fabry, Federica A Falconio ... Gregory J Hannon
Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
Purkinje cell collaterals regulate processing in the input layer of the cerebellum by providing fast stochastic GABAA-mediated and slow GABAB-mediated inhibition to a specialized subset of unipolar brush cells.
Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.
The statistics of binocular rivalry at different combinations of image contrast is reproduced quantitatively by competing out-of-equilibrium populations of independent neural assemblies with idealized attractor dynamics.
CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
Matthew C Bond, Lucia Vidakovic ... Carey D Nadell
Microfluidic culture and high-resolution 3-D microscopy establish that bacteriophages trapped in the outer matrix layers of a bacterial biofilm remain active and can prevent colonization of the biofilm by newly arriving bacteria.
Although flies cannot discriminate shock-paired and -unpaired odor 24 hr after single-trial aversive conditioning, they choose to avoid both of them, which is derived from a merged long-term memory.
A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
