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Page 937 of 1,838
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp, James DeGregori ... Frédéric Thomas
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

    Stefanie Deinhardt-Emmer, Daniel Wittschieber ... Gita Mall
    Early postmortem autopsy of COVID-19 patients shows high viral loads and damage of the lung, although extrapulmonary cells demonstrate no injury, they contribute to inflammation, hyper-coagulation, and multiple organ dysfunction.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission

    Jamie M Ellingford, Ryan George ... Graeme CM Black
    Characterisation of SARS-CoV-2 genomic divergence in healthcare-associated outbreaks demonstrates that the inclusion of healthcare workers in contact networks identifies additional links in SARS-CoV-2 transmission pathways.
    1. Genetics and Genomics

    DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

    Eilis Hannon, Emma L Dempster ... Jonathan Mill
    DNA methylation data can be harnessed to provide insights into molecular and phenotypic differences associated with the spectrum of psychosis diagnoses.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

    Sabrina Vullo, Nicolas Ambrosio ... Stephan Kellenberger
    Analysis of conformational changes indicates that activation of acid-sensing ion channels involves protonation of diverse extracellular sites and interaction of interdomain loops with the upper ends of transmembrane helices.
    1. Neuroscience

    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

    Magda L Atilano, Sebastian Grönke ... Linda Partridge
    Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.
    1. Developmental Biology
    2. Neuroscience

    The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli

    Nobuko Inoue, Hirofumi Nishizumi ... Hitoshi Sakano
    The critical period in the mouse olfactory system is defined by activity-dependent synapse formation induced by Semaphorin7A/PlexinC1 signaling in the neonatal glomeruli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner, Anders Barth ... Shimon Weiss
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.
    1. Neuroscience

    Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

    Jessica Mitchell, Carlas S Smith ... Scott Waddell
    Specific mRNAs localize to the dendrites of Drosophila mushroom body output neurons.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

    Michael Roland Wolff, Andrea Schmid ... Ulrich Gerland
    The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.