A new knock-in mouse endogenously labels cytotoxic granules and can be used with all modern super-resolution imaging techniques to study T cell function in vitro and in vivo.
Lucas D Serdar, DaJuan L Whiteside ... Kristian E Baker
Nucleotide resolution mapping of ribosome-bound RNA decay fragments in yeast cells expressing ATPase-deficient UPF1 reveals 3' UTR bound ribosomes and a role for UPF1 in post-termination ribosome recycling.
Specific and non-specific conformational confinement, via point mutation or cochaperone interaction or macro-molecular crowding, stimulates protein function in Hsp90 by reducing non-productive conformational flexibility.
Walter R Mancia Leon, Julien Spatazza ... Arturo Alvarez-Buylla
Pcdhg determine survival of the GABAergic cortical interneuron population that is necessary to establish and maintain proper excitatory to inhibitory balance in the cerebral cortex.
Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
Maria Luisa Saggio, Dakota Crisp ... William C Stacey
Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.
Steven M Markus, Matthew G Marzo, Richard J McKenney
The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.
Chiara La Rosa, Francesca Cavallo ... Luca Bonfanti
The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
