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Tau monomer from aggregate-containing cell models and tauopathy brains adopts discrete structures that act as templates, dictating the conformation of distinct strains that result from its seeding activity.

The transcriptional coactivator ppargc1a regulates the renal progenitor patterning to delineate boundary formation of differentiated segment populations during nephrogenesis.

Skeletal muscle performance sets the course of rapid speciation by defining the evolutionary trajectory of reproductive behavior.

Dopamine is able to ensure that neural networks maintain critical features of their output, such as synchrony of neuron firing, by directly increasing coupling strength to ensure robust output is maintained.

Ion conduction in the calcium-activated chloride channel TMEM16A is directly regulated by calcium, which binds to a site close to the pore thereby shaping the electrostatics at its intracellular entrance.

The mRNA of the apoptosis inducing death ligand CD95L/FasL kills cancer cells through RNAi after conversion into small RNAs that are loaded into the RNA-induced Silencing Complex.

The structure of the entire Mot1 Swi2/Snf2 protein uncovers an unexpected auto-inhibited resting state activated by substrate binding, and suggests a DNA pulling mechanism of TBP displacement.

The Drosophila response to injection of alpha-actinin reinforces the notion that exposure of cytoskeletal components acts as a sign of cell damage conserved throughout metazoan evolution.

Dopamine modulates behavioral measures of learning and pleasantness in a learning task guided by intrinsic reward, inducing long-term memory benefits specially in those participants with a high sensitivity to reward.

Greater connectivity of the descending pain modulatory system network in the infant brain is associated with lower pain-related brain activity.