Browse our Research Articles

Page 254 of 1,418
    1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh
    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
    1. Biochemistry and Chemical Biology

    A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    Magnus Chan, Harutyun Sahakyan ... David Fedida
    Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.
    1. Evolutionary Biology

    An armoured marine reptile from the Early Triassic of South China and its phylogenetic and evolutionary implications

    Andrzej S Wolniewicz, Yuefeng Shen ... Jun Liu
    A new fossil sheds light on the evolution of an aquatic lifestyle in extinct reptiles and supports a close phylogenetic relationship between archosaurs (crocodiles, dinosaurs, birds, and kin) and turtles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

    Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft
    Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
    1. Computational and Systems Biology

    A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties

    Dai Owaki, Volker Dürr, Josef Schmitz
    A near-linear relationship between electrical stimulus duration and resultant joint torque in stick insects has been unveiled, enhancing control strategies in biohybrid robotics.
    1. Ecology
    2. Plant Biology

    An ecological network approach for detecting and validating influential organisms for rice growth

    Masayuki Ushio, Hiroki Saito ... Atsushi J Nagano
    By leveraging quantitative environmental DNA metabarcoding and ecological network analysis, influential organisms in rice fields are identified, thereby revealing potential avenues for environmentally friendly agricultural practices.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    lncRNA read-through regulates the BX-C insulator Fub-1

    Airat Ibragimov, Xin Yang Bing ... Paul Schedl
    A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.
    1. Immunology and Inflammation
    2. Neuroscience

    Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

    René Lemcke, Christine Egebjerg ... Birgitte R Kornum
    Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.
    1. Neuroscience

    Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss

    Yaoxuan Wang, Mengda Jiang ... Hao Wu
    Innovative MRI mapping of the auditory pathway reveals that peripheral auditory structure significantly impacts the development of the central auditory-language network in children with profound sensorineural hearing loss, emphasizing the need for early speech input and tailored interventions.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.