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A thorough insight into the previously unrecognised role of a critical developmental regulator known as TBXT in influencing the specification of human trunk neural crest cells, the presumed precursors of the childhood tumour neuroblastoma.

Genetic variants acting between biologically related metabolite pairs often reflect biology local to the traits and have effect directions contrasting those of upstream or downstream variants, which can result in striking, biologically interpretable heterogeneity in genetic correlation across the genome.

Toll signaling modulates hemocyte differentiation into the megacyte lineage and their recruitment to the midgut greatly enhances mosquito immunity against Plasmodium.

The mechanism of substrate binding cooperativity in human thymidylate synthase does not derive from millisecond dynamic interconversion between active and inactive conformations in solution, but instead results primarily from differential changes in faster side-chain motions (conformational entropy), facilitated by a disordered N-terminus.

Caenorhabditis elegans utilize multiple strategies to optimize germline mitochondrial genome integrity at the foundational stage of gonad development.

Imaging studies of connexin-coupled networks of colorectal cancer cells reveal that cells carrying a genetic defect in an essential metabolic pathway can be rescued by diffusive exchange with neighboring wild-type cells via gap junctions, particularly Cx26, thereby evading negative selection.

Combined analyses of publicly available population-level variant data and detailed individual-level clinical data can be used to quantify the clinical impact of new SARS-CoV-2 variants in different settings.

A new mechanism of Rvb1/Rvb2 proteins was found that couples transcription, mRNA granular localization and translation of select genes during glucose starvation stress.

Organellar lipidomics and lipid reporter studies in intact cells reveal how disease-relevant mutations in a sphingolipid biosynthetic enzyme cause a wide-ranging perturbation of lipid distributions and membrane properties along the secretory pathway.

The ongoing stream of information that comes in through our senses is segmented into distinct neural states at each level of the cortical hierarchy, which underpins our experience of distinct events.