IL-33 plays an important role in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.
The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
Joseph Wayne M Fowler, Rong Zhang ... William C Sessa
Detailed biochemical and metabolic analysis of the inflammatory response in human endothelial cells reveals that inflammation directly regulates cholesterol homeostasis.
William Conway, Robert Kiewisz ... Daniel J Needleman
A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
Zebrafish caudal fin amputation induces an increase in the glycolytic influx that leads to dedifferentiation of osteoblasts and their re-entry in the cell cycle, which is essential for blastema formation and bone regeneration.
A computer model of the mouse visual cortex shows that local brain circuits are organized as switches whose states are coded as neuronal oscillations with different frequencies.
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder ... Henrik Oster
High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.
