Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.
Claudia C Carcamo, Matthew F Poyton ... Taekjip Ha
In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.
Under metabolic syndrome, joint subchondral preosteoclasts acquire a senescence-associated secretome, which causes a rapid structural alteration of subchondral bone and contributes to the development of osteoarthritis.
Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
Gabriel Renaud, Maibritt Nørgaard ... Søren Besenbacher
Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.
Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.
A method for the genetic manipulation of enteroendocrine cells reveals how different intestinal cell types control food intake and drive post-ingestive learning.
Kelly M Martyniuk, Arturo Torres-Herraez ... Christoph Kellendonk
Pharmacological and genetic studies in the mouse reveal how dopamine D2 receptors on cholinergic interneurons regulate cue-evoked changes in the levels of striatal acetylcholine and dopamine during behavior.
