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In a mouse model of DYT25 dystonia with disruption of striatal neurotransmission by Gnal mutation, the cerebello-thalamic excitability is increased following symptom expression and θ-burst cerebellar stimulations during cholinergic-induced dystonia depress the cerebello-thalamic transmission and reduce the motor symptom severity.

Using mass spectrometry to study protein composition of translating ribosomes under unstressed or stress conditions, aspartate aminotransferase 2 (Aat2) is identified as a metabolic enzyme with a moonlighting function in the yeast integrated stress-response pathway.

Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.

Phenotypic heterogeneity at the single-cell level of cellulosomal machinery biosynthesis suggests a division-of-labor strategy as revealed by the nanoscale mechanistic and ecological investigation of in situ structure and distribution of cellulosomes on bacteria while interacting with the cellulosic substrate.

Promoter studies identified BMP/Smad signaling as a transcriptional regulator of Ppif gene encoding cyclophilin D, a component of the mitochondrial permeability transition pore, and gain- and loss-of-function experiments determined how such regulation affects osteogenic differentiation.

Uphill migrations of lowland plants into warming alpine ecosystems may yield a positive climate feedback by accelerating soil microbial respiration and decreasing soil carbon content.

Temporally regulated RNA-binding proteins orchestrate RNA splicing to drive myogenesis.

The discovery of uncharacterized lncRNAs that regulate cell proliferation/growth across cancer types, including two p53 regulated tumor suppressive lncRNAs, were identified through systematic analyses of multi-omics data and provides a computational framework resource to cancer researchers.

Some deleterious mutations co-occurring within a genome can compensate each other, and this affects patterns of polymorphism, particularly in highly polymorphic species.

Cellular and vacuolar size expansion are coordinated.