Elvira Forte, Mirana Ramialison ... Milena B Furtado
Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.
VGF was identified as a factor secreted from thalamocortical axons essential for the cytoarchitectonic features of neocortical layer 4 in the sensory areas in mice.
Jennifer Patritti Cram, Jianqiang Wu ... Nancy Ratner
In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.
Joshua Hatterschide, Paola Castagnino ... Elizabeth A White
Papillomavirus E7 proteins activate the YAP1 oncogene in basal epithelial cells by degrading PTPN14, in doing so promoting basal cell retention and contributing to carcinogenesis.
Kelsie RS Doering, Xuanjin Cheng ... Stefan Taubert
Animal survival in hypoxia requires the classical hypoxia-inducible factor (HIF) signalling pathway, but in the nematode worm C. elegans, a new signalling pathway involving the nuclear receptor NHR-49/PPARalpha is as important for hypoxia survival as the HIF pathway.
Macrophages use integrin-dependent 3D movement and cell protrusiveness, which control cell motility and space exploration as a prerequisite for optimal clearance of particles and dead cells by macrophage networks.
A combination of electrophysiology and quantitative modeling shows that subtle changes in input due to adaptation in cone phototransduction control the linearity or nonlinearity of how ganglion cells integrate spatial inputs.
A cargo recognition α-helix was identified in Nup358, which is required for activation of a dynein-dependent transport pathway that is essential for brain development.
The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.
Giulia Di Felice, Giovanni Visci ... Paolo Boffetta
A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.
