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The relationship between APOE genotype and disease risks may be environmentally moderated, with APOE4 being less harmful and unlikely to increase cardiometabolic risk in a physically active, energy-limited population.

Radial alignment in confined cell monolayers with isotropic actin network is found to be mediated by the condensation tendency and tissue-scale actin gradient.

mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells.

Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.

Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.

METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.

Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.

Protein dynamics signatures in ageing collagen-rich tissues that are central to frequent age-related diseases such as osteoporosis and osteoarthritis.

Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.

The cryo-electron microscopy structures of inactive and active states of calcium-sensing receptor (CaSR) reveal the activation mechanisms of CaSR.