Browse our Research Articles

Page 618 of 1,446
    1. Neuroscience

    Distinct synaptic transfer functions in same-type photoreceptors

    Cornelius Schröder, Jonathan Oesterle ... Tom Baden
    The ribbon synapses of zebrafish UV-cone photoreceptors preferentially transmit transient or sustained components in light-stimuli depending on their location in the eye.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide, Yoshihiko Kobayashi ... Tomokazu Souma
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Biochemistry and Chemical Biology

    Structure-guided microbial targeting of antistaphylococcal prodrugs

    Justin J Miller, Ishaan T Shah ... Audrey R Odom John
    Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.
    1. Neuroscience

    Alpha oscillations and event-related potentials reflect distinct dynamics of attribute construction and evidence accumulation in dietary decision making

    Azadeh HajiHosseini, Cendri A Hutcherson
    Alpha oscillations represent an intermediate stage of evidence accumulation that is influenced by self-regulation in value-based decision making.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Cancer Biology
    2. Computational and Systems Biology

    Structural basis of the effect of activating mutations on the EGF receptor

    Ioannis Galdadas, Luca Carlino ... Francesco Luigi Gervasio
    Computational methods reveal how mutations affect the conformational landscape of the kinase domain of EGFR resulting in abnormal signaling and provide a structural framework for ongoing drug discovery efforts on mutant-specific EGFR inhibition.
    1. Structural Biology and Molecular Biophysics

    Structure and analysis of nanobody binding to the human ASIC1a ion channel

    Yangyu Wu, Zhuyuan Chen ... Cecilia M Canessa
    Development of specific and high-affinity nanobodies to probe the structure of human acid sensing ion channel-1a and as binding modifiers of the toxins PcTx and MitTx1.
    1. Developmental Biology
    2. Genetics and Genomics

    Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

    Yukiko Tando, Hitoshi Hiura ... Yasuhisa Matsui
    Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

    William F Richter, Rohan N Shah, Alexander J Ruthenburg
    FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Calponin-homology domain mediated bending of membrane-associated actin filaments

    Saravanan Palani, Sayantika Ghosh ... Darius Vasco Köster
    Combination of actin and curly on lipid membranes constitutes a new, minimalistic system to generate high curvature actin rings that can contract upon the action of myosin II filaments.