Seeing others genuinely experiencing pain vs. pretending to be in pain is distinctively tracked by neural processes related to affect sharing and self-other distinction, enabling individuals to precisely respond to others’ actual emotions and needs.
Teresa Romeo Luperchio, Leandros Boukas ... Hans T Bjornsson
Chromatin/transcriptome profiling in multiple mouse models with mutations in epigenetic machinery (EM) reveals shared abnormalities including many IgA-relevant genes, indicating that this kind of joint analysis may elucidate the multigenic nature of EM disorders.
Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
Michele Felletti, Cédric Romilly ... Kristina Jonas
Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
Alessandro Stirpe, Nora Guidotti ... Thomas Schalch
Clr4, a highly conserved SUV39 histone methyltransferase, requires its SET domain to sense histone H3K14 ubiquitination in order to maintain heterochromatin and H3K9 methylation.
The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
Stefan M Lemke, Dhakshin S Ramanathan ... Karunesh Ganguly
Sleep spindles, distinctive brain activity patterns occurring in non-REM sleep, modify cross-area connectivity in the motor network relevant for behavioral flexibility, impacting subsequent behavior.
Giulia Bandini, Sebastian Damerow ... Michael AJ Ferguson
The activity, localization, and essentiality of TbFUT1, together with its ability to complement Leishmania parasites lacking the homologous gene, suggest the presence of an uncommon and conserved mitochondrial fucosylation pathway required for kinetoplastid parasites viability.
