SWELL1 is required for basal, stretch, and flow-mediated endothelial AKT-eNOS signaling in vitro and protects against angiotensin-induced hypertension and diabetes-associated vascular dysfunction in vivo.
Savannah G Brovero, Julia C Fortier ... Michelle N Arbeitman
Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
SUSD4 loss-of-function induces misregulation of GLUA2 degradation and of synaptic plasticity suggesting a mechanism for its potential contribution to neurodevelopmental disorders.
Alex Macpherson, Maisem Laabei ... Jean MH van den Elsen
Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.
Jernej Turnšek, John K Brunson ... Andrew Ellis Allen
An iron-sensitive gene cluster encodes proteins that co-localize with phytotransferrin endosomes and are involved in key intracellular iron transformation and trafficking processes in a model marine diatom.
A computational model shows that it's possible to learn and replay extended temporal sequences in a network of spiking neurons with a modular architecture and a biologically realistic learning rule.
Anna Nagy-Staron, Kathrin Tomasek ... Calin C Guet
The phenotype of a gene regulatory network depends both qualitatively and quantitatively on the local genetic context of its individual components and cannot necessarily be predicted solely from network's topology.
Drake A Donovan, Johnathan G Crandall ... Jeffrey N McKnight
The identification of a novel mechanism of chromatin remodeling, including a conserved remodeler domain and regulatory epitopes, provides targets for the design of therapeutics to modulate transcriptional regulation in cells.
Xiaochen Fan, V Pragathi Masamsetti ... Patrick PL Tam
Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
