Browse our Research Articles

Page 639 of 1,477
    1. Cell Biology
    2. Developmental Biology

    Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

    Parvathy Ramesh, Nidhi Sharma Dey ... Lolitika Mandal
    Ecdysone-mediated regulation of Relish expression and activation in the hematopoietic niche is essential for progenitor maintenance in the Drosophila Lymph gland.
    1. Computational and Systems Biology
    2. Neuroscience

    Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

    Nadiatou T Miningou Zobon, Joanna Jędrzejewska-Szmek, Kim T Blackwell
    ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Patterns of within-host genetic diversity in SARS-CoV-2

    Gerry Tonkin-Hill, Inigo Martincorena ... Wellcome Sanger Institute COVID-19 Surveillance Team
    Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina, Jane Wang ... Kota Mizumoto
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

    Miriam S Weber, Matthias Eibauer ... Ohad Medalia
    Keratins assemble into tubular filaments with a central density and exhibit structural heterogeneity, which is reflected in alterations of the helical arrangement.
    1. Stem Cells and Regenerative Medicine

    Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

    Jacqueline A Larouche, Mahir Mohiuddin ... Carlos A Aguilar
    Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.
    1. Neuroscience

    Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

    Attila Ozsvár, Gergely Komlósi ... Gábor Tamás
    Summation of metabotropic GABAergic responses remain linear even if most superficial layer interneurons specialized to recruit GABAB receptors are simultaneously active.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Cancer Biology
    2. Cell Biology

    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

    Veethika Pandey, Alicia Fleming-Martinez ... Peter Storz
    Blockage of CXCL10/CXCR3 signaling between murine pancreatic precancerous lesion cells and inflammatory macrophages generates a tumor-promoting microenvironment.
    1. Chromosomes and Gene Expression

    High-resolution, genome-wide mapping of positive supercoiling in chromosomes

    Monica S Guo, Ryo Kawamura ... Michael T Laub
    GapR-seq enables the global mapping of positive supercoiling in bacteria and yeast, revealing positive supercoils downstream of highly expressed genes and, in yeast, associated with centromeres, pericentromeres, telomeres, replication origins, and R-loops.