Browse our Research Articles

Page 641 of 1,423
    1. Cell Biology
    2. Physics of Living Systems

    Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

    Manuel Giménez-Andrés, Tadej Emeršič ... Alenka Čopič
    The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.
    1. Neuroscience

    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

    Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
    Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
    1. Medicine
    2. Neuroscience

    PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

    Edoardo Bistaffa, Alba Marín-Moreno ... Fabio Moda
    The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
    1. Neuroscience

    Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1

    Rebecca A Mount, Sudiksha Sridhar ... Xue Han
    Large-scale imaging analysis of CA1 reveals that distinct neural networks are involved in trace conditioning versus extinction learning, shedding light on how the hippocampus encodes different types of memory.
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski, Clara S Tang ... Y Audrey Hay
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Physics of Living Systems

    Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

    Rinat Arbel-Goren, Valentina Buonfiglio ... Joel Stavans
    Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby, Candice L Clarke ... James E Peters
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Evolutionary Biology

    The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

    Joshua T Washington, Katelyn R Cavender ... Patricia J Moore
    The maintenance DNA methyltransferase DNMT1 is required for the transition of spermatogonia to spermatocytes both during larval testis development and adult sperm replenishment in the insect Oncopeltus fasciatus.
    1. Neuroscience

    Optimal policy for attention-modulated decisions explains human fixation behavior

    Anthony I Jang, Ravi Sharma, Jan Drugowitsch
    A normative decision-making model that incorporates an information-limiting attention bottleneck is able to qualitatively replicate human behavior and make novel predictions that are verified in data.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega, Sylvain Monnier ... Giovanni Cappello
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.