Manuel Giménez-Andrés, Tadej Emeršič ... Alenka Čopič
The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.
Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
Edoardo Bistaffa, Alba Marín-Moreno ... Fabio Moda
The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
Large-scale imaging analysis of CA1 reveals that distinct neural networks are involved in trace conditioning versus extinction learning, shedding light on how the hippocampus encodes different types of memory.
Przemyslaw Jarzebowski, Clara S Tang ... Y Audrey Hay
Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
Rinat Arbel-Goren, Valentina Buonfiglio ... Joel Stavans
Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
Joshua T Washington, Katelyn R Cavender ... Patricia J Moore
The maintenance DNA methyltransferase DNMT1 is required for the transition of spermatogonia to spermatocytes both during larval testis development and adult sperm replenishment in the insect Oncopeltus fasciatus.
A normative decision-making model that incorporates an information-limiting attention bottleneck is able to qualitatively replicate human behavior and make novel predictions that are verified in data.
Monika E Dolega, Sylvain Monnier ... Giovanni Cappello
Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.