Browse our Research Articles

The primer extension and 5' flap processing activities of DNA polymerase I are physically coordinated by combined movements of the DNA substrate and the 5' nuclease domain of the enzyme.

Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.

Phase separation of two-component multivalent systems is suppressed at rational polymer stoichiometries, suggesting possible cellular strategies for regulating the formation and function of biomolecular condensates.

IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.

Endoglycan fine-tunes the interaction between guidance molecules and surface receptors during axon guidance and cell migration.

Data-driven and effective connectivity analyses reveal patterns of functional specialization, common mechanisms, and brain-wide interaction profiles within the human inferior parietal lobes for multiple functional domains.

In medaka fish, the reduction of cystic proliferation of germ stem cells declines gametogenesis, reproduction success, and male sexual behavior, with a decrease of mating vigor.

A theory is presented for the optimal design of cellular sensing systems that maximizes the sensing precision given resource constraints.

Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.

Although the phasic activity of midbrain dopamine neurons is known to represent reward values, these neurons displayed a tonic firing mode to continuously track reward values changing moment-by-moment.