Browse our Research Articles

Page 643 of 1,403
    1. Neuroscience

    Drp1 is required for AgRP neuronal activity and feeding

    Sungho Jin, Nal Ae Yoon ... Sabrina Diano
    Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.
    1. Neuroscience

    Distinct neural mechanisms underlie subjective and objective recollection and guide memory-based decision making

    Yana Fandakova, Elliott G Johnson, Simona Ghetti
    Neural substrates of objective vs. subjective memory states can be distinguished, including their role in supporting decisions aimed at optimizing performance.
    1. Biochemistry and Chemical Biology

    Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

    Víctor M Hernández-Rocamora, Natalia Baranova ... Waldemar Vollmer
    The synthesis of bacterial cell wall peptidoglycan was reconstituted in lipid bilayers and detected by a novel Förster resonance energy transfer real-time assay.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

    Christopher Icke, Freya J Hodges ... Ian R Henderson
    AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

    Carlos AZ Bassetto, João Luis Carvalho-de-Souza, Francisco Bezanilla
    A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.
    1. Microbiology and Infectious Disease

    Redox controls RecA protein activity via reversible oxidation of its methionine residues

    Camille Henry, Laurent Loiseau ... Benjamin Ezraty
    RecA is inactivated by oxidative stress and repaired by the MsrA/B anti-ROS defense system.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell, Christopher G Wilson ... Timothy G Barraclough
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

    Alicia Tapias, David Lázaro ... Zhao-Qi Wang
    The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.
    1. Cell Biology

    LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

    Nana Naetar, Konstantina Georgiou ... Roland Foisner
    The lamin A/C binding protein LAP2α inhibits formation of higher order lamin structures in the nuclear interior in a lamin A/C-phosphorylation-independent manner, thereby regulating chromatin mobility.
    1. Microbiology and Infectious Disease

    Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

    Darryl A Wesener, Zachary W Beller ... Jeffrey I Gordon
    A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.