Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.
The statistics of binocular rivalry at different combinations of image contrast is reproduced quantitatively by competing out-of-equilibrium populations of independent neural assemblies with idealized attractor dynamics.
CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
Although flies cannot discriminate shock-paired and -unpaired odor 24 hr after single-trial aversive conditioning, they choose to avoid both of them, which is derived from a merged long-term memory.
A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
Gisela Rangel-Yescas, Cecilia Cervantes ... Leon D Islas
Proton channels are present in reef-building corals and constitute important molecular players that should help understand calcification and the response of these organisms to ocean acidification.
Adult microglia are born by the division of single surviving microglia that rapidly acquire mature morphologies and functions in order to perform their physiological roles in the brain.