Browse our Research Articles

Page 643 of 1,423
    1. Neuroscience

    Neural signatures of vigilance decrements predict behavioural errors before they occur

    Hamid Karimi-Rouzbahani, Alexandra Woolgar, Anina N Rich
    Declined coding of sensory information in the brain reflects human vigilance decrements and allows prediction of behavioural errors.
    1. Medicine
    2. Neuroscience

    Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

    Shenhab Zaig, Carolina da Silveira Scarpellini, Gaspard Montandon
    Emerging approaches in larval zebrafish to identify safe opioid therapies without the side-effect of respiratory depression.
    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay, Sahar I El Shair ... Murray J Cairns
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

    Luke Stephen Tain, Robert Sehlke ... Linda Partridge
    Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.
    1. Computational and Systems Biology
    2. Neuroscience

    Visuomotor learning from postdictive motor error

    Jana Masselink, Markus Lappe
    Visual, motor, and forward model gains learn from a postdictive update of space to keep perception and saccadic motor function aligned.
    1. Neuroscience

    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

    Diptendu Mukherjee, Ben Jerry Gonzales ... Ami Citri
    The ventrolateral striatum is found to be recruited during the encoding of cocaine preference, within which Egr2-expressing ensembles are functionally important, as is the expression of Egr2 within them.
    1. Microbiology and Infectious Disease

    Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers

    Qing Yang, Nicholas R Meyerson ... Sara L Sawyer
    A quick and portable test makes saliva samples turn yellow when people are carrying SARS-CoV-2, the virus that causes COVID-19.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Global epistasis emerges from a generic model of a complex trait

    Gautam Reddy, Michael M Desai
    Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
    1. Neuroscience

    Analysis of ultrasonic vocalizations from mice using computer vision and machine learning

    Antonio HO Fonseca, Gustavo M Santana ... Marcelo O Dietrich
    An open-source tool based on computational vision and machine learning shows high accuracy and sensitivity in the analysis of ultrasonic vocalizations.
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers, Hanaa Hariri ... W Mike Henne
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.