Browse our Research Articles

Page 644 of 1,403
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez, Lena Israitel ... Amir Orian
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore, Michael G Alvarado ... Scott Earley
    Activation of TRPA1 channels on cerebral capillary endothelial cells initiates a retrograde signal that propagates and dilates upstream arterioles.
    1. Neuroscience

    Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

    Timothy S Balmer, Carolina Borges-Merjane, Laurence O Trussell
    Extracellular levels of the neurotransmitter glutamate are maintained at physiologically significant levels at some synapses even in the absence of action potentials.
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang, Maria Gracia Gervasi ... Ingolf Bach
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Repeated outbreaks drive the evolution of bacteriophage communication

    Hilje M Doekes, Glenn A Mulder, Rutger Hermsen
    Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.
    1. Neuroscience

    Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses

    Aaron J Norris, Jordan R Shaker ... Michael R Bruchas
    Warm-activated parabrachial neurons contain overlapping dynorphin and enkephalin expressing subpopulations, project to preoptic hypothalamus, and mediate behavioral and physiological thermal defenses behaviors.
    1. Genetics and Genomics
    2. Neuroscience

    Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age

    Jessica M Sidisky, Daniel Weaver ... Daniel Babcock
    Maintaining synaptic structure and function over time requires continuous signaling from pathways that are crucial for synapse development.
    1. Developmental Biology

    Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Mamoru Ishii, Tomoko Tateya ... Tsuyoshi Hirashima
    Live-cell imaging and mathematical modeling reveal the physical basis of collective cell migration underlying spiral cochlear duct formation during murine inner ear development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Emergence and diversification of a highly invasive chestnut pathogen lineage across southeastern Europe

    Lea Stauber, Thomas Badet ... Daniel Croll
    The chestnut blight fungus has successfully established an intermediary, diverse European bridgehead population, giving rise to a highly invasive clonal lineage spreading across southeastern Europe.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental hourglass and heterochronic shifts in fin and limb development

    Koh Onimaru, Kaori Tatsumi ... Shigehiro Kuraku
    Omics approaches reveal conserved and diversified gene regulation between fin and limb development.