Larissa Melo do Nascimento, Franziska Egler ... Esteban Erben
A robust procedure to purify mRNAs and their associated proteins identify CFB2 as the critical protein that binds and influences the fate of the main virulence factor in Trypanosoma brucei.
Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
Circuit tracing and in vivo calcium imaging reveals neurons conveying polarized light information from photoreceptors to the central brain, transforming patterns in the sky into a directional cue for navigation.
Terkild B Buus, Alberto Herrera ... Sergei B Koralov
Oligo-conjugated antibodies are a powerful tool but require thorough optimization to reduce background signal, increase sensitivity, and reduce sequencing costs.
Robert J Nichols, Benjamin LaFrance ... David F Savage
A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.
Transcription changes in cells taken from bronchoalveolar fluid of COVID-19 patients indicate severe disruption of coagulation and fibrinolytic pathways in the lung and suggest similar processes in other organs.
Martin Jinye Zhang, Angela Oliveira Pisco ... James Zou
Comprehensive single-cell transcriptome analysis reveals global and tissue-specific aging markers and characterizes the heterogeneous aging status of different cell types and tissues in mouse.
Neuronal junctophilins 3 and 4 similarly recruit and functionally modify P/Q and N-type calcium channels, but differentially recruit the three ryanodine receptor isoforms to endoplasmic reticulum-plasma membrane junctions.
