Browse our Research Articles

Page 678 of 1,378
    1. Neuroscience
    2. Physics of Living Systems

    Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters

    Mahmut Demir, Nirag Kadakia ... Thierry Emonet
    Visualized odor encounters show that Drosophila navigate spatiotemporally complex odor plumes using random walks biased by the timing of brief and unpredictable odor encounters.
    1. Developmental Biology
    2. Neuroscience

    Direct glia-to-neuron transdifferentiation gives rise to a pair of male-specific neurons that ensure nimble male mating

    Laura Molina-García, Carla Lloret-Fernández ... Richard J Poole
    A novel developmental mechanism generates a previously undescribed pair of sex-specific proprioceptive neurons required for male-specific behaviour.
    1. Cell Biology

    Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast

    Tomoyuki Fukuda, Yuki Ebi ... Tomotake Kanki
    Atg43 serves as a selective autophagy receptor by tethering isolation membranes to mitochondria to promote mitophagy and plays a mitophagy-independent role that facilitates normal cell growth in fission yeast.
    1. Cell Biology
    2. Genetics and Genomics

    Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

    Fabrizio Orsenigo, Lei Liu Conze ... Elisabetta Dejana
    Single-cell RNA analysis of brain endothelium identifies the angiogenic venous capillary subset and respective resident endothelial progenitors at the origin of CCM lesions, while arterial endothelial cells are unaffected.
    1. Neuroscience

    Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding

    Joeri BG van Wijngaarden, Susanne S Babl, Hiroshi T Ito
    An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.
    1. Neuroscience

    Typical and atypical language brain organization based on intrinsic connectivity and multitask functional asymmetries

    Loïc Labache, Bernard Mazoyer ... Nathalie Tzourio-Mazoyer
    Left-hander's atypical language brain organization, revealed by task-induced rightward asymmetry, is underpinned at rest by homotopic networks wired for language bilaterally and strong intrinsic connectivity through a large corpus callosum.
    1. Cell Biology

    A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells

    Ce Zhang, Yue Chen ... Qingyu Wu
    A conserved motif in corin and CD320 LDL receptor modules regulates specific apical trafficking in polarized renal epithelial cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

    Roman O Fedoryshchak, Magdalena Přechová ... Richard Treisman
    Interaction of cofactor Phactr1 with PP1 creates a composite substrate-binding surface that defines the sequence specificity of the Phactr1/PP1 holoenzyme.
    1. Neuroscience

    Dopamine promotes instrumental motivation, but reduces reward-related vigour

    John P Grogan, Timothy R Sandhu ... Sanjay G Manohar
    Dopaminergic medication dissociates contingent motivation from reward expectation effects on invigoration of movements in PD patients, confirming they are separate processes with different dopaminergic functions.
    1. Cancer Biology

    Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

    Hao Zhang, Yang Zhang ... Chunliang Li
    The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.