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An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.

Sleep-related hemodynamic signals are much larger than those in the awake brain, so it is crucial to monitor the arousal state during studies of spontaneous activity.

Trans-synaptic protein interactions are required for synapse specification and function, and the combination between neuroligin3 and αneurexin1 controls inhibitory synaptic function in a splice isoform- and interneuron-specific manner.

Cholinergic populations with distinct cellular birthdates innervate deep versus superficial layers of the cortex with exquisite specificity.

PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.

Neuregulins control the integration of specific excitatory and inhibitory synapses through subcellular sorting.

The architecture of flagellated chambers in sponge pumps is linked to that of body plan, supporting the current view that the sponge aquiferous system evolved from an open-type filtration system.

Just as the sinoatrial node acts as pacemaker for the heart, the nucleus acts as pacemaker for the Xenopus embryonic cell cycle.

Microbiomediversity favors further diversity in a positive feedback that is strongest in lower-diversity biomes but which plateaus as niches are increasingly filled in higher-diversity biomes.

A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.