Casein kinase 1G2 interacts with and inhibits the activation of receptor-interacting kinase 3, RIP3, in response to TNF and toll-like receptor family members and attenuates its necroptosis signaling activity.
Novel capsaicin analogs with conserved chemistry but varying sizes were used as molecular rulers to investigate energetics of conformational changes in the ligand-binding pocket and mechanisms of TRPV1 ligand-gating.
Casey Paquola, Oualid Benkarim ... Boris C Bernhardt
A novel model of the human mesiotemporal lobe suggests that its broad roles in cognition can be explained by how its cytoarchitecture and form relate to large-scale functional motifs.
Lotte P Watts, Toyoaki Natsume ... Anne D Donaldson
The RIF1-long and short splice variants show distinct ability to protect cells from replication stress by promoting 53BP1 nuclear bodies, representing the first described functional difference between the two variants.
İbrahim Avşar Ilik, Michal Malszycki ... Tuğçe Aktaş
Re-characterization of the targets of a commonly used nuclear speckle marker unexpectedly leads to the discovery of the elusive core of the nuclear speckles.
