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Mesencephalic origin of the zebrafish thalamocortical-like visual projection neurons indicates independent evolution of tectofugal visual pathways in amniotes and teleosts.

EphrinB2/EphB4-mediated regulation of cytoskeletal contractility is a key homeostatic mechanism of lymphatic endothelial cell-cell junction maintenance, and provides a potential target for therapeutic modulation of lymphatic vessel permeability and function.

Computational and theoretical models show that rate adaptation of phase responses can regulate Purkinje cell outputs by forming transient oscillations in fast-spiking neurons.

Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.

Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.

The human Fibrodysplasia-Ossificans-Progressiva BMP-receptor mutant signals in zebrafish in the absence of ligand-binding, displays BMP ligand-responsive hyperactivity, neither requiring other type-I-BMP receptors, unlike wild-type, challenging views of the pathological mechanism.

Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.

The metabolic readout of endothelial function in the microvessels-on-a-chip facilitates mechanistic studies and detection of biomarkers for microvascular diseases in a physiological relevant environment.

Upon deletion of threonine deaminases, biosynthesis of isoleucine is rescued by two promiscuous reactions, one emerges under aerobic conditions and the other is naturally active under anaerobic conditions.

The strongest peak frequency of brain oscillations in a brain area decreases significantly, gradually and robustly along the posterior-anterior axis following the global hierarchy from early sensory to higher order areas.