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Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.

Lumen formation by single epithelial cells depends on FGF-signalling-dependent expression of a spectraplakin, which can be functionally replaced by Tau.

The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.

A neuron-specific circular RNA keeps neuronal differentiation in check by lowering transcription rates from key neuronal marker genes.

Closure of the cranial neural tube, which is essential for mammalian development, is driven by spatially and temporally patterned cell remodeling events that require positionally regulated Sonic hedgehog signaling.

A trial of mitofusin activation shows neuron regeneration and phenotype reversal in vitro and in vivo in experimental Charcot–Marie–Tooth disease type 2A caused by mitofusin 2 mutations.

Whole genome duplication in Brassica rapa is accompanied by both expansion of the circadian transcriptome and widespread temporal reconfiguration of gene regulatory networks consistent with subfunctionalization among pairs of paralogs.

Cryo-electron microscopic structures of 5-HT₃A receptor in complex with first and second generations of clinically used setron reveal the molecular basis for their binding modes and mechanisms of inhibitory action.

Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.

A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.