Browse our Research Articles

Page 725 of 1,393
    1. Ecology

    Antagonistic effects of intraspecific cooperation and interspecific competition on thermal performance

    Hsiang-Yu Tsai, Dustin R Rubenstein ... Sheng-Feng Shen
    By integrating theoretical and empirical approaches, the results show that linking abiotic factor and biotic interactions on the niche width will be critical for understanding species-specific responses to climate change.
    1. Cell Biology
    2. Medicine

    Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

    Hosni Cherif, Daniel G Bisson ... Lisbet Haglund
    Targeting senescent cells in human intervertebral discs, using senotherapeutics, provides a potential therapeutic strategy to prevent or reduce disc degeneration and pain.
    1. Neuroscience

    Learning prediction error neurons in a canonical interneuron circuit

    Loreen Hertäg, Henning Sprekeler
    The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.
    1. Stem Cells and Regenerative Medicine

    Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

    Lisa Zipper, Denise Jassmann ... Tobias Reiff
    A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
    1. Ecology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of nested Darwinian populations and the emergence of community-level heredity

    Guilhem Doulcier, Amaury Lambert ... Paul B Rainey
    Artificial selection on communities drives the evolution of interactions and establishes community-level inheritance.
    1. Developmental Biology
    2. Neuroscience

    Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity

    Arani Roy, Jason J Osik ... Stephen D Van Hooser
    The development of neural responses proceeds through both the expansion and contraction of receptive field structure, and in addition depends upon changes in excitability of individual cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

    Ilia Korobko, Hisham Mazal ... Amnon Horovitz
    Protein stability in the cage formed by the chaperonin GroEL and its cofactor GroES is reduced by more than 5 kcal mol-1 relative to that in bulk solution.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes, Chaoran Li ... K Christopher Garcia
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Neuroscience

    Can sleep protect memories from catastrophic forgetting?

    Oscar C González, Yury Sokolov ... Maxim Bazhenov
    Computational modeling predicts that sleep replay plays a protective role against catastrophic forgetting by revealing synaptic mechanisms allowing overlapping populations of neurons to store multiple interfering memories.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

    Marina Schrecker, Julia Korobenko, Richard K Hite
    Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.