Thomas Michael Ernst, Anna Evelina Brol ... Dagmar Timmann
Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
Matthew F Pech, Linda E Fong ... Jeffrey Settleman
CRISPR/Cas9 screens reveal a role for the ubiquitin ligase substrate adaptor DCAF15 in the immune surveillance of cancer cells by natural killer cells.
Yung-Chi Huang, Jennifer K Pirri ... Mark J Alkema
Caenorhabditis elegans studies indicate that gain-of-function mutations in the presynaptic voltage-gated calcium, associated with familial hemiplegic migraine in humans, result in excitatory-inhibitory imbalance in the nervous system.
Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.
Joseph G Duman, Shalaka Mulherkar ... Kimberley F Tolias
The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
Changes in neural response dynamics observed with visual learning provide a novel means to dissect synaptic plasticity and its interplay with slow negative feedback via firing rate adaptation.