The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.
Ann-Kathrin Rößling, Kai Dünser ... Jürgen Kleine-Vehn
The methylation status of pectin acts as a critical signalling scaffold for RALF peptides, linking extracellular matrix dynamics to peptide hormone-mediated regulation of plant root growth.
Yucheng Liang, Jean-Emmanuel Hugonnet ... Michel Arthur
The Braun lipoprotein is tethered to peptidoglycan independently from the insertion of newly-synthesized peptidoglycan subunits into the expanding cell wall generating a dynamic equilibrium between free and bound protein forms.
Evgenia Leikina, Jarred M Whitlock ... Leonid Chernomordik
Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.
