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Page 374 of 1,792
    1. Neuroscience

    Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

    Dongsheng Xiao, Yuhao Yan, Timothy H Murphy
    Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
    1. Neuroscience

    Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

    Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser
    A computational and translational approach to measuring anxiety-related behaviour was validated in two large independent samples, presenting opportunities for cross-species anxiety research and potential implications for anxiolytic drug development.
    1. Structural Biology and Molecular Biophysics

    Mechanism of substrate binding and transport in BASS transporters

    Patrick Becker, Fiona Naughton ... Alexander D Cameron
    The putative substrate pantoate binds to a sodium-coupled secondary transporter of the bile acid sodium symporter family, with sodium-dependent binding and conformational changes consistent with an elevator mechanism of transport.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems genetics approaches for understanding complex traits with relevance for human disease

    Hooman Allayee, Charles R Farber ... Aldons J Lusis
    Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.
    1. Epidemiology and Global Health

    The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

    Victoria P Mak, Kami White ... Loic Le Marchand
    During the COVID-19 pandemic, cancer-related screening and healthcare practices varied (by age, race/ethnicity, education, and comorbidities), and considering these differences in high-risk individuals' monitoring is important as undiagnosed cases or poor prognosis may increase due to delayed screening/treatment.
    1. Neuroscience

    Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila

    Budhaditya Chowdhury, Lakshman Abhilash ... Orie Shafer
    Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.
    1. Developmental Biology

    Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

    Akihiro Miura, Hemanta Sarmah ... Munemasa Mori
    The Foxa2 lineage-based organ generative strategy allows us to establish a unique paradigm for the simultaneous generation of functional whole lungs and thymus, which can be applied to future transplantation therapy.
    1. Biochemistry and Chemical Biology

    High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls

    Ya-Chen Hsu, Pin-Rui Su ... Cheng-Chih Hsu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin-dependent lateral organ initiation

    Elmehdi Bahafid, Imke Bradtmöller ... Rüdiger GW Simon
    Mutant and gene expression analyses shows that phytohormones and mobile transcription factors interact to coordinate organ formation with stem cell maintenance in the plant shoot meristem.