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Page 455 of 1,892
    1. Neuroscience

    A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis

    Antonio Cerdán Cerdá, Nicola Toschi ... Silvia De Santis
    MRI is sensitive to the increase in axonal caliber due to pathology and was used to detect widespread increase in the average axonal caliber in multiple sclerosis brains with short disease duration only.
    1. Developmental Biology

    Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    Notch signaling specifies binary neuronal fates through its integration with primary homeodomain activity.
    1. Neuroscience

    Experience shapes chandelier cell function and structure in the visual cortex

    Koen Seignette, Nora Jamann ... Christiaan N Levelt
    Chandelier cells in primary visual cortex show experience-dependent plasticity, respond strongly to behaviorally relevant stimuli and only weakly inhibit pyramidal cells.
    1. Ecology

    Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

    Pooja Dongre, Gaëlle Lanté ... Erica van de Waal
    New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    BRAIDing receptors for cell-specific targeting

    Hui Chen, Sung-Jin Lee ... Yang Li
    A novel strategy to activate the WNT pathway in a cell type selective manner by linking designer ligands with target cell specific bridging receptors.
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Neuroscience

    Balance of activity during a critical period tunes a developing network

    Iain Hunter, Bramwell Coulson ... Richard A Baines
    Neurodevelopmental critical periods act to integrate activity to encode homeostatic set points that remain fixed thereafter.
    1. Ecology
    2. Evolutionary Biology

    Fin whale song evolution in the North Atlantic

    Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
    The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
    1. Immunology and Inflammation

    Ym1 protein crystals promote type 2 immunity

    Ines Heyndrickx, Kim Deswarte ... Bart N Lambrecht
    Protein crystallization is a rare event yet Ym1 crystals made from a chitinase-like protein are abundantly found in eosinophilic airway inflammation, where they promote type 2 immunity.
    1. Chromosomes and Gene Expression

    Gle1 is required for tRNA to stimulate Dbp5 ATPase activity in vitro and promote Dbp5-mediated tRNA export in vivo in Saccharomyces cerevisiae

    Arvind Arul Nambi Rajan, Ryuta Asada, Ben Montpetit
    In vivo and in vitro characterization demonstrates a direct interaction of Dbp5 with tRNA that requires Gle1 to spatially activate the Dbp5 ATPase cycle for tRNA export in Saccharomyces cerevisiae.