Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

   Jessica Jocher, Philipp Janssen ... Ines Hellmann

   Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.
2. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Investigating the native functions of [NiFe]-CODH through genomic context analysis

   Maximilian Böhm, Henrik Land

   Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO₂ reduction.
3. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

   Yuzhen Liu, Christopher D McGann ... Devin K Schweppe

   DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modification.
4. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

   Caleb Hallinan, Hyun Joo Ji ... Jean Fan
5. 1. Neuroscience
   2. Computational and Systems Biology

   Opening the black box: a modular approach to spike sorting

   Samuel Garcia, Chris Halcrow ... Pierre Yger
6. 1. Computational and Systems Biology

   A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

   Jiayue Yang, James Wang, Justine Cléry
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

   Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
8. 1. Computational and Systems Biology

   Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability

   Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
9. 1. Computational and Systems Biology
   2. Neuroscience

   Visual information is broadcast among cortical areas in discrete channels

   Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith

   Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
10. 1. Computational and Systems Biology

    Anatomical basis of sex differences in the electrocardiogram identified by three-dimensional torso-heart imaging reconstruction pipeline

    Hannah J Smith, Blanca Rodriguez ... Abhirup Banerjee