Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    REPOP: bacterial population quantification from plate counts

    Pedro Pessoa, Carol Lu ... Steve Pressé
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Atomistic Simulation of Voltage Activation of a Truncated BK Channel

    Zhiguang Jia, Jianhan Chen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

    Natalia A Shevtsova, Andrew B Lockhart ... Simon M Danner
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments

    Terence Li, Marcus Alvarez ... Noah Zaitlen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Computational and Systems Biology

    The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

    Lucas Fuentes Valenzuela, Paul Francois, Jan Skotheim
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

    András Ecker, Daniela Egas Santander ... Michael W Reimann
    A new framework for exploring the mechanisms underlying learning in cortical microcircuits is established.
    1. Computational and Systems Biology

    A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

    HaDi MaBouDi, Mark Roper ... James AR Marshall
    Active vision dynamically refines spatiotemporal neural representations, optimising visual processing through scanning behaviour and non-associative learning, providing insights into efficient sensory encoding in dynamic environments.
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Highlights

    1. Computational and Systems Biology

    Methylation and mRNA metabolism

    Sarah Hallstein, Julian König
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors