Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience
    2. Computational and Systems Biology

    The Origin of Movement Biases During Reaching

    Tianhe Wang, Ryan J Morehead ... Richard B Ivry
    1. Computational and Systems Biology
    2. Developmental Biology

    Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo

    Juan Manuel Gomez, Hendrik Nolte ... Maria Leptin
    An encompassing resource of differentially phosphorylated proteins forms the basis for identifying missing links in cell fate determination and morphogenesis, including, for example, microtubules as mediators of different functions in cells along the dorso-ventral axis.
    1. Computational and Systems Biology

    TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

    Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Combining mutation and recombination statistics to infer clonal families in antibody repertoires

    Natanael Spisak, Gabriel Athènes ... Aleksandra M Walczak
    HILARy is a new algorithm for grouping B-cell receptor sequences into distinct lineages, a crucial task to analyze immune response and memory through repertoire sequencing.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho
    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
    1. Computational and Systems Biology

    Establishing comprehensive quaternary structural proteomes from genome sequence

    Edward Alexander Catoiu, Nathan Mih ... Bernhard Palsson

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors