Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology

   The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

   Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson

   A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.
2. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   The interplay between biomolecular assembly and phase separation

   Giacomo Bartolucci, Ivar S. Haugerud ... Christoph A. Weber
3. 1. Computational and Systems Biology

   Predicting metabolic modules in incomplete bacterial genomes with MetaPathPredict

   David Geller-McGrath, Kishori M Konwar ... Jason E McDermott

   MetaPathPredict is a novel bioinformatics tool that makes accurate predictions of KEGG module presence within highly incomplete bacterial genomes.
4. 1. Cell Biology
   2. Computational and Systems Biology

   Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokines on muscle regeneration

   Megan Haase, Tien Comlekoglu ... Silvia S. Blemker
5. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

   Gaetan De Waele, Gerben Menschaert, Willem Waegeman
6. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Experimental evolution for the recovery of growth loss due to genome reduction

   Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying

   Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
7. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Context-Aware Amino Acid Embedding Advances Analysis of TCR-Epitope Interactions

   Pengfei Zhang, Seojin Bang ... Heewook Lee
8. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

   Taegon Chung, Iksoo Chang, Sangyeol Kim

   ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.
9. 1. Neuroscience
   2. Computational and Systems Biology

   Decoding contextual influences on auditory perception from primary auditory cortex

   B. Englitz, S. Akram ... S. Shamma
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

    Lauren Kuffler, Daniel A Skelly ... Gregory W Carter

    Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.