Medicine

Latest articles

1. 1. Medicine
   2. Microbiology and Infectious Disease

   HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

   Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra

   Transcriptomic profiling of HERV elements at the loci level differentiates ME/CFS, fibromyalgia, and their overlap, revealing distinct immuno-epigenetic landscapes.
2. 1. Medicine

   Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

   Shahriar Mowla, Linda Farahani ... Channa N Jayasena

   There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
3. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

   M Reza Bahrani Fard, Jessica Chan ... C Ross Ethier
4. 1. Cell Biology
   2. Medicine

   AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

   Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
5. 1. Cell Biology
   2. Medicine

   Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice

   Shuo He, Lei Huang ... Jinlong He

   Endothelial-specific supplementation with Aff3ir-ORF2 significantly ameliorated disturbed flow-induced endothelial activation and the development of atherosclerotic plaques, highlighting its promising therapeutic potential for the treatment of atherosclerosis.
6. 1. Genetics and Genomics
   2. Medicine

   EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

   Lianlei Wang, Xinyu Yang ... Nan Wu
7. 1. Medicine
   2. Neuroscience

   mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

   Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
8. 1. Medicine
   2. Neuroscience

   Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR

   Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
9. 1. Medicine
   2. Neuroscience

   Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

   Tomohiro Umeda, Ayumi Sakai ... Takami Tomiyama

   Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
10. 1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop

    Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.