Systems genetics works to understand how genetic diversity translates into phenotypic diversity by studying how information is transmitted from the genome through RNA, proteins and beyond.
It aims to explain how complex traits are influenced by many loci, at the organismal level and how this is influenced by environmental diversity as well as non-genetic and non-environmental factors.
Systems genetics also relies on the comprehensive multi-omics analysis of cells, tissues and organs, and attempts to integrate the information embedded in these networks so that we can better understand complex human diseases and other biological problems that remain somewhat intractable.
This Special Issue brings together research in this growing field.
To mark this publication the editors together with leaders in the field of systems genetics have written a Review Article which aims to describe some of the resources and tools of systems genetics, so that researchers in all areas of biology and medicine can make use of the data.
Note: Due to the timing of the call for papers, some articles included in this Special Issue were accepted for publication before the introduction of our new publishing model.