5,470 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    In situ single particle classification reveals distinct 60S maturation intermediates in cells

    Bronwyn A Lucas, Kexin Zhang ... Nikolaus Grigorieff
    Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.
    1. Cancer Biology

    Molecular classification and tumor microenvironment characteristics in pheochromocytomas

    Sen Qin, Yawei Xu ... Zheng Zhang
    ScRNA-seq of diverse pheochromocytoma patients reveals distinct microenvironment characteristics and supports an informative molecular classification system.
    1. Ecology

    Regularities in species’ niches reveal the world’s climate regions

    Joaquín Calatayud, Magnus Neuman ... Martin Rosvall
    Similarities in climatic niches of terrestrial vertebrates indicate the Earth's climate regions, which differ among groups and from previous plant-based climate classifications.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cancer type classification using plasma cell-free RNAs derived from human and microbes

    Shanwen Chen, Yunfan Jin ... Pengyuan Wang
    Both human and microbe cell-free RNA features in plasma could distinguish tumors of different primary locations.
    1. Cell Biology
    2. Computational and Systems Biology

    DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

    Xinxin Wang, Zhiming Chen ... Gaudenz Danuser
    A new user-intervention-free classification, using single-fluorescent markers, measures conventionally unmeasureable phenotypes in early stages during clathrin-mediated endocytosis.
    1. Cell Biology

    Intelligent classification of platelet aggregates by agonist type

    Yuqi Zhou, Atsushi Yasumoto ... Keisuke Goda
    An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure

    Romain F Laine, Gemma Goodfellow ... Clemens F Kaminski
    Machine learning in conjunction with super-resolution imaging allows for the first time to quantitatively analyse large and heterogenous virus samples structure at a high throughput and specificity.
    1. Neuroscience

    Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus

    Diek W Wheeler, Charise M White ... Giorgio A Ascoli
    Hippocampome.org is an online resource that provides free human- and machine-readable access to the comprehensive property-based classification of hippocampal neurons from 14,000 pieces of published experimental evidence.
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.

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