1,756 results found
    1. Cell Biology
    2. Developmental Biology

    Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

    Nikki Coleman-Gosser, Yanhui Hu ... Amanda Simcox
    Lineage-specific Drosophila cell lines provide in vitro models for cell, biochemical, and high-throughput analyses in defined cell types.
    1. Cancer Biology
    2. Cell Biology

    Axon-like protrusions promote small cell lung cancer migration and metastasis

    Dian Yang, Fangfei Qu ... Julien Sage
    In small cell lung cancer, the transition from a neuroendocrine state to a more neuronal state endows these cancer cells with increased migration and metastatic potential.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom, Chaolin Zhang ... Robert B Darnell
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Neuroscience

    Subcellular proteomics of dopamine neurons in the mouse brain

    Benjamin D Hobson, Se Joon Choi ... Peter A Sims
    APEX2 proximity labeling of genetically targeted neurons enables subcellular and cell type-specific proteomics in the mouse brain, revealing the axonal and somatodendritic proteomes of midbrain dopaminergic neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    NetPyNE, a tool for data-driven multiscale modeling of brain circuits

    Salvador Dura-Bernal, Benjamin A Suter ... William W Lytton
    The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.
    1. Neuroscience

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

    Jason D Vevea, Edwin R Chapman
    Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

    James C McGann, Jon A Oyer ... Gail Mandel
    Poised neuronal genes are repressed by REST and Polycomb in embryonic stem cells independently and via different chromatin modifications.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Little skate genome provides insights into genetic programs essential for limb-based locomotion

    DongAhn Yoo, Junhee Park ... Myungin Baek
    The generation of high-quality little skate reference genome enables molecular mechanism studies of gene regulation.
    1. Neuroscience

    Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Laura E Mickelsen, William F Flynn ... Alexander C Jackson
    Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.

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