Katie Abley, Pau Formosa-Jordan ... James CW Locke
Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.
Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
Comprehensive genome-wide associations studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.
Raisa Bailon-Zambrano, Juliana Sucharov ... James T Nichols
Within populations, there is standing variation in paralog expression levels, paralog expression levels are heritable, and variation in paralog expression can modify the phenotypes associated with mutation of one of the paralogs.
Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
Matthew WK Wong, Anbupalam Thalamuthu ... Perminder S Sachdev
A minor subset of plasma lipids are heritable, and this is associated with gene expression of transcripts related to roles beyond lipid metabolism, including immune function and cell signalling.
The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain