4,339 results found
    1. Computational and Systems Biology
    2. Plant Biology

    An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

    Katie Abley, Pau Formosa-Jordan ... James CW Locke
    Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin, Naama Katsowich ... Nathalie Q Balaban
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Evolutionary Biology

    A scenario for an evolutionary selection of ageing

    Tristan Roget, Claire Macmurray ... Michael Rera
    Ageing is broadly accepted as a by-product of evolution, as thus, models allowing to conceive ageing as an adaptive force of evolution could show significant importance at a time of biogerontology mostly aiming at curing ageing.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression variability in human and chimpanzee populations share common determinants

    Benjamin Jung Fair, Lauren E Blake ... Yoav Gilad
    Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha, Maryam Kohram, Hanna Salman
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Genetics and Genomics

    Genetic architecture of natural variation of cardiac performance from flies to humans

    Saswati Saha, Lionel Spinelli ... Laurent Perrin
    Comprehensive genome-wide associations studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.
    1. Developmental Biology
    2. Genetics and Genomics

    Variable paralog expression underlies phenotype variation

    Raisa Bailon-Zambrano, Juliana Sucharov ... James T Nichols
    Within populations, there is standing variation in paralog expression levels, paralog expression levels are heritable, and variation in paralog expression can modify the phenotypes associated with mutation of one of the paralogs.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz, Daniel Backenroth ... Shai Carmi
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
    1. Developmental Biology
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen, Marta Koch ... Bassem A Hassan
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability

    Eric Mandela, Christopher J Stubenrauch ... Iain D Hay
    The bacterial periplasm must adapt to factors effecting the width of the cell envelope.

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