A complex colour polymorphism which links colour with behavioural and life-history traits is associated with a single gene duplication in male wood tiger moths.

Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.

A single-nucleotide I232T polymorphic change in FcγRIIB's transmembrane domain bends FcγRIIB's ectodomains toward cell membrane to allosterically hinder FcγRIIB's ligand association, providing novel molecular mechanism for functional loss of FcγRIIB-I232T.

The evolution columbine genus involved frequent mixing between incipient species, and one chromosome appears to have taken its own path.

Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.

Interactions between a mobile resistance gene and chromosomal mutations drive the evolution of high-level antibiotic resistance.

A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.

The effect of balancing selection on the human genome is greater than previously appreciated, especially affecting large deletion variations.

Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.

Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.