The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.

Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.

C-terminus mediated inhibition is one emerging modality of intervention for L-type Ca²⁺ channels, which coordinate multiple motifs to acutely tune Ca²⁺ current and Ca²⁺ influx down to the lower limits preset by end-stage Ca²⁺-dependent inactivation.

eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.

A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.

Institutions should value teaching and service, and not just research, when considering faculty for promotion and tenure.

The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.

Repression of the G protein-coupled chemokine receptor CCR5 enhances MAPK/CREB signaling, long-term potentiation, somatosensory cortical plasticity, and learning and memory, while CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits.

A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.