20,382 results found
    1. Ecology
    2. Physics of Living Systems

    Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

    Amir Erez, Jaime G Lopez ... Ned S Wingreen
    Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
    1. Structural Biology and Molecular Biophysics
    2. Stem Cells and Regenerative Medicine

    ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation

    Nataliya Nady, Ankit Gupta ... Joanna Wysocka
    The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis

    Jun Chen, Na Xu ... Rongwen Xi
    A newly discovered feedback amplification loop between stem cells and their immediate daughter progenitor cells drives epithelial regeneration and tumor development.
    1. Cell Biology
    2. Plant Biology

    Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

    Samuel James Watson, Na Li ... R Paul Jarvis
    The small ubiquitin-like modifier system directly regulates components of the chloroplast protein import apparatus, that is, TOC proteins, to control chloroplast biogenesis and plant development.
    1. Neuroscience

    Cortical encoding of acoustic and linguistic rhythms in spoken narratives

    Cheng Luo, Nai Ding
    In the processing of spoken narratives, bottom-up acoustic cues and top-down linguistic knowledge separately contribute to neural construction of linguistic units.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

    Wan Hua Li, Ke Huang ... Yong Juan Zhao
    The first-in-class cell-permeant fluorescent probe provides direct and visual evidence of SARM1 activation in axonal degeneration and identified the first covalent, allosteric inhibitor of SARM1 acting on the NAD-binding pocket in the ARM domain.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

    Nan Wang, Jing He ... Kehkooi Kee
    The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.
    1. Developmental Biology

    Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4

    Jianlin Liang, Nan Wang ... Kehkooi Kee
    In vitro reprogramming of human fibroblasts to Sertoli-like cells with immunosuppressive properties provides platforms for basic research and clinical application.
    1. Microbiology and Infectious Disease

    GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

    Saba Naz, Kumar Paritosh ... Vinay Kumar Nandicoori
    Genome sequence analysis of Mycobacterium tuberculosis clinical isolates and subsequent validation in laboratory and animal infection models identify previously unrecognized genetic mutations in DNA repair genes that contribute to the development of drug resistance.
    1. Neuroscience

    Drp1 is required for AgRP neuronal activity and feeding

    Sungho Jin, Nal Ae Yoon ... Sabrina Diano
    Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.

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