The Mtgr1 protein promotes the maintenance of pluripotency and germ cell formation via its interaction with the stem cell regulator Prdm14.

Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.

C-terminus mediated inhibition is one emerging modality of intervention for L-type Ca²⁺ channels, which coordinate multiple motifs to acutely tune Ca²⁺ current and Ca²⁺ influx down to the lower limits preset by end-stage Ca²⁺-dependent inactivation.

eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.

A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.

Institutions should value teaching and service, and not just research, when considering faculty for promotion and tenure.

The occupation of a sub-pocket near the Na⁺-binding site in D₂R by the Na⁺-insensitive antagonists is the structural basis for their greater inverse agonism than that of the Na⁺-sensitive ligands.

Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO₃ precipitation under changing environmental conditions.

A fast evolutionary approach to engineer membrane protein kinetic stability yields folded excitatory neurotransmitter transporters and provides insights into their denaturing pathway.