Lowering endosomal pH through inhibition of sodium-hydrogen exchanger 6 corrects the ApoE4-induced Reelin resistance and restores neuronal glutamate receptor trafficking.

The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.

Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.

An ancestral apical brain center contributed to the evolution of the insect central complex requiring foxQ2, which is essential for the development of midline structures of the insect brain.

In stau^-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.

Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.

A single-cell landscape of acral melanoma and the intermolecular regulatory relationships between microenvironments.

The PVN-mPFC OT circuit is an important target for the treatment of disorders related to early adverse experiences.

A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.

Gαq stimulates HDAC5 phosphorylation by PKC-independent PKD/PKCμ activation to induce the IκB expression and limit the NF-κB-mediated inflammatory response which essential for proper endometrial decidualization and early pregnancy.