Nicholas M Grebe, Jean Paul Hirwa ... Stacy Rosenbaum
Mountain gorillas, who live in close-knit social groups with siblings and non-siblings of both sexes throughout their lives, show distinct behavioral biases towards maternal versus paternal kin.
Cell culture adaptation of SARS-CoV-2 is prevented on human airway cells with an active serine protease-mediated entry pathway, allowing the production of genetically stable virus stocks for laboratory experiments.
Sheldon JJ Kwok, Daniel T Montoro ... Vladimir Vinarsky
Live imaging of cells in an intact murine tissue combined with single-cell sequencing reveals a unique transcriptional signature of an observed cellular behavior.
Vitor H Teixeira, Parthiban Nadarajan ... Sam M Janes
Cell replenishment within the airways is governed by the random division of a population of basal progenitor cells, in a process that is accelerated in smokers.
The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory medicine.
Magda Spella, Ioannis Lilis ... Georgios T Stathopoulos
Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
Autofluorescence imaging permits label-free cell type identification in live airway tissue and reveals the dynamic formation of airway secretory cell associated antigen passages.
Maria R Stupnikov, Ying Yang ... Wellington V Cardoso
Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.