The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.

The establishment of forward genetics in S. rosetta reveals the first gene known to be required for choanoflagellate multicellular development.

While Dectin-1 is a well-known C-type lectin receptor recognizing b-glucan and involved in anti-fungal immunity, human Dectin-1 is O-glycosylated and acts as a ligand for another C-type lectin receptor, CLEC-2, expressed by platelets that mediates homeostatic responses such as lymphangiogenesis.

The multiple PDZ domain protein recruits Notch ligands to Nectin-2, which increases Notch signaling activity during angiogenesis.

Correlated magnetic resonance imaging and ultramicroscopy resolves macro- and microvasculature in glioma models and allows treatment monitoring of antiangiogenic therapy.

The first inhibitor identified against an iso-enzyme that initiates O-glycosylation in the Golgi complex promises new therapeutic approaches for cancer and chronic kidney disease.

The newly opened genome of a kleptoplastic mollusk, Plakobranchus ocellatus, indicated that sequestered plastids retain their activity within the animal cell without horizontal algal gene transfer to the animal nucleus.

X-ray crystallographic and atomic force microscopic analyses reveal the tilted homodimer structure and unanticipated dynamic characteristics of canine distemper virus-hemagglutinin (CDV-H), providing insights into the molecular and dynamic processes of Morbillivirus for cell entry, effective immunizations, and vaccine/drug design.

Impairment of protein N-glycosylation disrupts neural cell adhesion mediated by highly glycosylated members of the IgSF-CAM protein family.